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Product details

名称

ON-013100

分子类型

小分子

英文别名

MS-26627 | Q27281151 | ON013100 | ON-013100 | GHPUSRLWNSTQIK-BQYQJAHWSA-N | HY-112822 | Phenol, 2-methoxy-5-(((2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)- | UNII-J3I19I491A | (E)-2-methoxy-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)phenol | Phenol,

英文名称

ON-013100

货号

O646809-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression. In Vitro ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro . ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI 50 =6.7-11.2 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Cdk4/cyclin D1

生化机理

ON-013100 是一种抗肿瘤药物，是一种有丝分裂抑制剂，可抑制 Cyclin D1 的表达。

CAS号

865783-95-5

分子式

C19H22O7S

分子量

394.44 g/mol

PubChem编号

11269418

Isomeric SMILES

COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)O

IIUPAC Name

2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenol

INCHI

1S/C19H22O7S/c1-23-14-10-18(25-3)15(19(11-14)26-4)7-8-27(21,22)12-13-5-6-17(24-2)16(20)9-13/h5-11,20H,12H2,1-4H3/b8-7+

InChi Key

GHPUSRLWNSTQIK-BQYQJAHWSA-N

Smiles

COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)O

PubChem CID

11269418

关联CAS

865783-95-5

MeSH Entry Terms

(E)-2,4,6-trimethoxystyryl-3- hydroxy-4-methoxybenzyl sulfone;ON 013100;ON013100

溶解性

DMSO : 25 mg/mL (63.38 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

394.109 Da

单同位素质量Monoisotopic Mass

394.109 Da

拓扑极表面积Topological Polar Surface Area

99.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

557.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.600

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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