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Product details

名称

OXFBD04

分子类型

小分子

英文名称

OXFBD04

货号

O647678-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

OXFBD04 is a potent and selective BRD4 inhibitor with an IC 50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity In Vitro OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth. OXFBD04 (10 µM; for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines Concentration: 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 hours Result: Inhibited cancer cell lines growth. In Vivo OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t 1/2 =388 min). OXFBD04 has CL int of 3.57 µL/min/mg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:BRD4 166 nM (IC 50 )

生化机理

OXFBD04 是一种强效的选择性 BRD4 抑制剂，IC 50 为 166u202fnM。OXFBD04 是一种强效的 BET 溴链配体，对 CREBBP 溴链具有适度的亲和力。OXFBD04 具有抗癌活性。

CAS号

2231747-03-6

分子式

C17H16N2O3

分子量

296.32 g/mol

PubChem编号

145925690

Isomeric SMILES

CC1=C(C(=NO1)C)C2=CC(=CC(=C2)O)C(C3=CN=CC=C3)O

IIUPAC Name

3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(pyridin-3-yl)methyl]phenol

INCHI

1S/C17H16N2O3/c1-10-16(11(2)22-19-10)13-6-14(8-15(20)7-13)17(21)12-4-3-5-18-9-12/h3-9,17,20-21H,1-2H3

InChi Key

RFDVEAHRRMEOHK-UHFFFAOYSA-N

Smiles

CC1=C(C(=NO1)C)C2=CC(=CC(=C2)O)C(C3=CN=CC=C3)O

PubChem CID

145925690

溶解性

DMSO : ≥ 250 mg/mL (843.68 mM)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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