ODN 2336 is a A-Class CpG ODN (oligodeoxynucleotides), is a potent TLR9 agonist. ODN 2336 induces the production of IFN-α. ODN 2336 up-regulates the expression of IP-10 mRNA and IL-18 mRNA. ODN 2336 can be used as adjuvant of vaccines . In Vitro ODN 2336 (0.5 µM; 24, 48 h) up-regulates the expression of f CD69 and IFN-α. ODN 2336 (3 µg/ml; 4 h) stimulates strang transcription of IP-10 mRNA after 4 h in human PBMC. ODN 2336 (3 µg/ml; 2, 4, 16 h) up-regulates the expression of IL-18 mRNA at the 16 htime point. ODN 2336 (50 μg/mL; 20 h) with IL-3 (10 ng/mL) induces the production of IFN-α in the plasma of adult and cord blood. ODN 2336 (0.3125-5 µg/ml; 24 h) increases the production of FNA1 in a dose-dependent manner in human PBMCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid