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Product details

名称

Orexin 2 Receptor Agonist

分子类型

小分子

别名

食欲素 2 受体激动剂

英文名称

Orexin 2 Receptor Agonist

货号

O648381-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively. Form:Solid

生化机理

Orexin 2 受体激动剂是一种强效（对 OX2R 的 EC50 值为 23 nM）且具有 OX2R 选择性（OX1R/OX2R EC50 比值为 70）的激动剂：催产素 2 受体激动剂不仅具有强大的活性，而且还具有高选择性。

CAS号

1796565-52-0

分子式

C32H34N4O5S

分子量

586.7 g/mol

PubChem编号

91810287

Isomeric SMILES

CC1=CC(=CC=C1)C(=O)NCCNC2=CC(=CC=C2)NS(=O)(=O)C3=C(C=CC(=C3)C4=CC(=CC=C4)C(=O)N(C)C)OC

IIUPAC Name

N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide

INCHI

1S/C32H34N4O5S/c1-22-8-5-10-25(18-22)31(37)34-17-16-33-27-12-7-13-28(21-27)35-42(39,40)30-20-24(14-15-29(30)41-4)23-9-6-11-26(19-23)32(38)36(2)3/h5-15,18-21,33,35H,16-17H2,1-4H3,(H,34,37)

InChi Key

RHLMXWCISNJNDH-UHFFFAOYSA-N

Smiles

CC1=CC(=CC=C1)C(=O)NCCNC2=CC(=CC=C2)NS(=O)(=O)C3=C(C=CC(=C3)C4=CC(=CC=C4)C(=O)N(C)C)OC

PubChem CID

91810287

溶解性

DMSO : ≥ 32 mg/mL (54.54 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

586.225 Da

单同位素质量Monoisotopic Mass

586.225 Da

拓扑极表面积Topological Polar Surface Area

125.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

986.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.800

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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