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Product details

名称

Org41841

分子类型

小分子

别名

组织41841

英文别名

英文名称

Org41841

货号

O648726-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor ( LHCGR ) and thyroid-stimulating hormone receptor ( TSHR ) with EC 50 s of 0.2 and 7.7 μM, respectively. In Vitro Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC 50 s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC 50 of 800 nM. M9 responds to Org41841 with an improved EC 50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)

生化机理

Org41841 是促黄体生成素/绒毛膜促性腺激素受体（LHCGR）和促甲状腺激素受体（TSHR）的部分激动剂，其 EC 50 s 分别为 0.2 和 7.7 μM。

CAS号

301847-37-0

分子式

C19H22N4O2S2

分子量

402.53 g/mol

PubChem编号

9887381

Isomeric SMILES

CC(C)(C)NC(=O)C1=C(C2=C(N=C(N=C2S1)SC)C3=CC(=CC=C3)OC)N

IIUPAC Name

5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-methylsulfanylthieno[2,3-d]pyrimidine-6-carboxamide

INCHI

1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)

InChi Key

DVSFSADBOJYPGF-UHFFFAOYSA-N

Smiles

CC(C)(C)NC(=O)C1=C(C2=C(N=C(N=C2S1)SC)C3=CC(=CC=C3)OC)N

PubChem CID

9887381

关联CAS

301847-37-0

MeSH Entry Terms

Org 41841;Org-41841;Org41841

溶解性

DMSO : 100 mg/mL (248.43 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

402.118 Da

单同位素质量Monoisotopic Mass

402.118 Da

拓扑极表面积Topological Polar Surface Area

144.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

530

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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