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Product introduction

ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' In Vitro ODN 20844 (0.01-10 μM, 24 h) can effectively block TLR9-mediated IFN-α release and inhibit IL-6 secretion in human peripheral blood mononuclear cells. ODN 20844 (0.01-10 μM, 24 h) has better inhibitory effect on imiquimod-induced IL-6 secretion in human B cells than INH-ODN 2088. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TLR7 TLR9

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Chinese name

ODN 20844

English name

ODN 20844

Chinese alias

域名 20844

English alias

CAS number

1964506-29-3

molecular formula

molecular weight

4872.90 g/mol

Exact mass

≥96%

PSA

Logp

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