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Product details

名称

O6BTG-octylglucoside

别名

O6BTG-辛基葡萄糖苷

英文名称

O6BTG-octylglucoside

货号

O650080-5mg

包装规格

5mg

浓度

≥95%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

O6BTG-octylglucoside is a potent O 6 -methylguanine-DNAmethyl-transferase ( MGMT ) inhibitor, with IC 50 s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. In Vitro O6BTG-octylglucoside is a potent and non-toxic MGMT inhibitor, with IC 50 s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MGMT 32 nM (IC 50 )

生化机理

O6BTG 辛基葡萄糖苷是一种强效的 O 6 -甲基鸟嘌呤-DNA 甲基转移酶（MGMT）抑制剂，在体外（细胞提取物）的 IC 50 s 为 32 nM，在 HeLa S3 细胞中为 10 nM。

CAS号

382607-78-5

分子式

C24H34BrN5O7S

分子量

616.53 g/mol

PubChem编号

10438805

Isomeric SMILES

C1=C(SC=C1Br)COC2=NC(=NC3=C2N=CN3CCCCCCCCO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)N

Smiles

C1=C(SC=C1Br)COC2=NC(=NC3=C2N=CN3CCCCCCCCO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)N

PubChem CID

10438805

溶解性

DMSO : 100 mg/mL (162.20 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

615.136 Da

单同位素质量Monoisotopic Mass

615.136 Da

拓扑极表面积Topological Polar Surface Area

206.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

709

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.1

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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