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Product introduction

Orvepitant maleate (GW823296 maleate) 是一种有效，选择性、耐受性良好的 neurokinin-1 (NK-1) 受体拮抗剂，对人 neurokinin-1 受体的 pKi 为 10.2。Orvepitant maleate 可以穿越血脑屏障。Orvepitant maleate 可用于抑郁症和慢性顽固性咳嗽的研究。 Orvepitant maleate (GW823296 maleate) is potent, selective and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.

Specs ⸢ View details ⸥

Chinese name

Orvepitant maleate

English name

Orvepitant maleate

Chinese alias

马来酸奥维匹坦

English alias

(2R,4S)-4-[(8aS)-6-oxo-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide;(Z)-but-2-enedioic acid | AKOS040742349 | Q27279833 | GW823296B | GW-823

CAS number

579475-24-4

molecular formula

C35H39F7N4O6

molecular weight

744.70 g/mol

Exact mass

≥99%

PSA

122.000 Å²

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