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Product introduction

PI-103 Hydrochloride 是一种有效的 PI3K 和 mTOR 抑制剂，抑制 p110α，p110β，p110δ，p110γ，mTORC1 和 mTORC2，IC50 分别为 8 nM，88 nM，48 nM，150 nM，20 nM 和 83 nM。PI-103 Hydrochloride 也可抑制DNA-PK，IC50 为 2 nM。PI-103 Hydrochloride 诱导自噬 (autophagy)。 Product description PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.

Specs ⸢ View details ⸥

Chinese name

PI 103 盐酸盐

English name

PI 103 hydrochloride

Chinese alias

3-[4-(4-吗啉基吡啶基[3',2'：4,5]呋喃[3,2-d]嘧啶-2-基]苯酚盐酸盐

English alias

CAS number

371935-79-4

molecular formula

C19H16N4O3.HCl

molecular weight

384.82 g/mol

Exact mass

≥97%

PSA

84.500 Å²

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