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Product introduction

PYR-41 是一种选择性，可透过细胞的泛素活化酶 E1 抑制剂，IC50 值小于10 μM，对E2和E3基本无作用。产品应用： PYR-41已被用作E1抑制剂：用于确定腺相关病毒（AAV）转导的细胞降解途径通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）E2/E3分析，评估其选择性和效力处理高葡萄糖培养基中完全分化的C2C12肌管，以确定其对蛋白质泛素化和细胞活力的影响预处理人脑微血管内皮细胞（hBMEC），用于细菌感染前的抑制研究

Specs ⸢ View details ⸥

Chinese name

PYR-41,泛素激活酶（E1）抑制剂

English name

PYR-41

Chinese alias

4-[4-[(5-硝基-2-呋喃基)亚甲基]-3,5-二氧代-1-吡唑烷基]苯甲酸乙酯

English alias

4-[4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester | ethyl 4-(4-((5-nitrofuran-2-yl)methylene)-3,5-dioxopyrazolidin-1-yl)benzoate | Spectrum2_001078 | ETHYL 4-{4-[(5-NITROFURAN-2-YL)METHYLIDENE]-3,5-DIOXOPYRAZOLIDIN-1-

CAS number

418805-02-4

molecular formula

C17H13N3O7

molecular weight

371.3 g/mol

Exact mass

≥99%

PSA

135.000 Å²

Logp

2.300

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