前列腺素E2乙醇酰胺是PGE2的类似物，具有改善的水溶性和稳定性，已证明具有诱导HT29和HCA7 / C29人结肠直肠癌（CRC）细胞系凋亡的能力。已显示出对所有四种已知的EP受体亚型（EP1-EP4）起激动剂的作用，但亲和力明显小于PGE2。该化合物被认为是通过COX-2从前体anandamide（内源性大麻素神经递质）生物合成的。这些前列腺素类似物对于这些复杂的生化途径的反卷积中所用的结构活性研究是必不可少的，并且在这种情况下证明了独特而适用的生化活性。 Prostaglandin E2 Ethanolamide is an analog of PGE2 with improved water solubility and stability that has demonstrated the ability to induce apoptosis in HT29 and HCA7/C29 human colorectal carcinoma (CRC) cell lines. Shown to act as an agonist with all four known EP receptor subtypes (EP1 - EP4), but with an affinity that is significantly less than PGE2. This compound is thought to be biosyntesized via COX-2 from the precursor anandamide , the endogenous cannabinoid neurotransmitter. These prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways, and in this case demonstrates unique and applicable biochemical activity.