- exposure pathway： 口服, 浸润, 肌肉注射
- Toxicity summary： 普鲁卡因主要通过抑制钠离子通过电压门控钠通道进入神经元细胞膜来发挥作用。当钠离子内流被中断时，动作电位无法产生，信号传导因此被抑制。受体位点被认为位于钠通道的胞质(内部)部分。普鲁卡因还被证明能够结合或拮抗N-甲基-D-天冬氨酸(NMDA)受体以及烟碱乙酰胆碱受体和血清素受体-离子通道复合物的功能。
- Regulatory information： 新西兰化学品状态清单：盐酸普鲁卡因：没有单独批准，但可在适当的团体标准下使用
- Toxicity Data： LD50: 350 mg/kg (口服，小鼠)。
- ecotoxicity value： USDA APHIS化学品影响: collection=usda_chemeffect&query_type=synonym&query='^51-05-8$'
- Symptoms and Signs： 过敏反应(呼吸困难；喉咙紧闭；嘴唇、舌头或面部肿胀；或荨麻疹)；胸痛或心跳缓慢或不规则；头晕或嗜睡；焦虑或不安；恶心或呕吐；颤抖、发抖或癫痫发作(惊厥)。其他不太严重的副作用，如注射部位周围麻木、刺痛或轻微疼痛，更可能发生。(L1459)
- Other safety information： 化学品评估：IMAP评估 - 苯甲酸, 4-氨基-, 2-(二乙基氨基)乙酯, 单盐酸盐：人类健康一级评估
- Hazard categories and classifications： STOT SE 1 (22.8%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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Research chemical 1ml
Research chemical 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.
