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Product introduction

PF-00477736是一个强有力的，有选择性的ATP竞争性的小分子抑制剂，抑制Chk1,此Chk1带有0.49 nM的Ki。该化合物废除DNA损伤诱导的细胞周期阻滞和提高临床重要的化疗药物的细胞毒性，包括吉西他滨和卡铂。 PF-00477736 is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. The compound abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin.

Specs ⸢ View details ⸥

Chinese name

PF-477736,Chk1抑制剂, 检查点激酶 1 抑制剂

English name

PF-477736

Chinese alias

English alias

(2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0,4,13]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide | SCHEMBL13599879 | DTXSID401025875 | H11453 | NSC800848 | NSC-800848 | PF 00477736 | PF-736,PF-00477736 | DB

CAS number

952021-60-2

molecular formula

C22H25N7O2

molecular weight

419.48 g/mol

Exact mass

PSA

130.000 Å²

Logp

1.5

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