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returns

Product introduction

Pralsetinib (Blu667) 是高效的、选择性的RET 抑制剂。它能够抑制 WT RET (IC50:0.4 nM)，RET 突变体 V804L (IC50:0.3 nM)，V804M (IC50:0.4 nM)，M918T (IC50:0.4 nM) 和 CCDC6-RET (IC50:0.4 nM) 的融合。 Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion).

Specs ⸢ View details ⸥

Chinese name

普拉替尼（BLU-667）, 激酶插入域受体抑制剂

English name

Pralsetinib (BLU-667)

Chinese alias

English alias

:PRALSETINIB [ORANGE BOOK] | BLU123244 | BLU-123244 | X581238 | X-581238 | WHO 11004 | BDBM435010 | Pralsetinib [USAN] | SCHEMBL18789228 | cyclohexanecarboxamide, N-[(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methy

CAS number

2097132-94-8

molecular formula

C27H32FN9O2

molecular weight

533.6 g/mol

Exact mass

PSA

136.000 Å²

Logp

3.100

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