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Product introduction

（ - ）-埃博霉素B是一种微管（MT）的稳定药物,来自于天然粘细菌Sorangium cellulosum，是大环内酯类抗肿瘤因子。EpoB与EpoA相似的生物学特性。然而，在有效对抗P -糖蛋白表达多药耐药（MDR）细胞(IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells)，EpoB药效10倍于EpoA。（ - ）-埃博霉素B类似于紫杉醇，并在细胞生长中可替代紫杉醇。 EpoB导致细胞周期停滞(IC50 = 3.5 nM).。

Specs ⸢ View details ⸥

Chinese name

埃博霉素B, 微管蛋白稳定剂

English name

Epothilone B

Chinese alias

English alias

CAS number

152044-54-7

molecular formula

C27H41NO6S

molecular weight

507.68 g/mol

Exact mass

≥98%(HPLC)

PSA

137.000 Å²

Logp

4.2

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