Pyrotinib dimaleate (SHR-1258 dimaleate) 是有效、选择性的 EGFR/HER2 双重抑制剂，IC50 值分别为 13 nM 和 38 nM。 Pyrotinib dimaleate is a potent and selective dual inhibitor of EGFR/HER2 with IC50s of 13 and 38 nM, respectively. Information Pyrotinib (SHR-1258, BLTN, Pyrroltinib) dimaleate is a potent and selective irreversible dual tyrosine kinase inhibitor ofEGFRandHER2with IC50 of 0.013 μM and 0.038 μM, respectively. Targets EGFR (Cell-free assay); HER2 (Cell-free assay) 0.013 μM; 0.038 μM In vitro Pyrotinib (SHR1258), as an EGFR/HER2 dual tyrosine kinase inhibitor, shows excellent in vitro potency, selectivity, and favorable PK profiles. In vivo Pyrotinib (SHR1258) displays robust anti-tumor effects on HER2-overexpressing xenograft models and sufficiently safety windows in animals as well as favorable pharmacokinetic properties in human. Cell Research(from reference) Cell lines：A431, SK-BR-3, NCI-N87 Concentrations：6-7 concentrations (not specific) Incubation Time：72 h