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Product details

名称

PD 151746

分子类型

小分子

别名

3-(5-氟-1H-吲哚-3-基)-2-巯基-2-丙酸

英文名称

PD 151746

货号

P422187-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

敏感性

对空气和光敏感

产品介绍

PD151746是有效的、选择性的钙蛋白酶抑制剂。PD151746抑制 u-calpain (Ki = 0.26 ± 0.03 μM) 选择性比抑制 m-calpain (Ki = 5.33 ± 0.77μM) 高20倍。 Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

生化机理

细胞可渗透的选择性非肽钙蛋白酶抑制剂（钙蛋白酶1和钙蛋白酶2的K i值分别为0.3和5μM）。通过hFPR / hFPRL1激活刺激吞噬细胞功能。与Ca 2+钙蛋白酶位点相互作用。

CAS号

179461-52-0

分子式

C11H8FNO2S

分子量

237.25 g/mol

PubChem编号

5353866

Isomeric SMILES

C1=CC2=C(C=C1F)C(=CN2)/C=C(/C(=O)O)\S

IIUPAC Name

(Z)-3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid

INCHI

1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-

InChi Key

HWMQHECFXSVZGN-KMKOMSMNSA-N

Smiles

C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S

PubChem CID

5353866

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

237.026 Da

单同位素质量Monoisotopic Mass

237.026 Da

拓扑极表面积Topological Polar Surface Area

54.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

321.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.500

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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