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Product introduction

PKM2-IN-1 是一种丙酮酸激酶 M2 (PKM2) 抑制剂，其 IC50 值为 2.95 μM。 Information PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. Targets PKM2 (Cell-free assay) 2.95 μM In vitro The well performing compound 3k shows nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18-1.56 μM. Moreover, compound 3k exhibits more cytotoxicity on cancer cells than normal cells. Cell Research(from reference) Cell lines：HCT116, Hela, H1299, BEAS-2B Concentrations：0.078, 0.156, 0.313, 0.625 μM Incubation Time：48 h

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Chinese name

PKM2抑制剂(化合物3k)

English name

PKM2 inhibitor(compound 3k)

Chinese alias

English alias

1-Piperidinecarbodithioic acid,(1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)methyl ester

CAS number

94164-88-2

molecular formula

C18H19NO2S2

molecular weight

345.48 g/mol

Exact mass

10mM in DMSO

PSA

94.800 Å²

Logp

3.500

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