泊马度胺-PEG₂-炔烃

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(prop-2-yn-1-yloxy)ethoxy)propanamide | Crosslinker–E3 Ligase ligand conjugate | Template for synthesis of targeted protein degrader

Pomalidomide-PEG₂-Alkyne

P463546-50mg

50mg

≥95%

避光,-20°C储存,充氩

超低温冰袋运输

对湿度敏感；对光敏感

Description Protein degrader builiding block Pomalidomide-PEG2-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

C21H21N3O7

427.41 g/mol