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Product introduction

PHA 543613 是一种特异性 α7 nAChR 激动剂 (Ki = 8.8 nM) ，可用于阿尔茨海默病和精神分裂症认知缺陷的研究。应用 PHA-543613已被用于研究其在接受β-淀粉样蛋白（Aβ）25-35-治疗小鼠中识别记忆和神经血管偶联（NVC）反应中的作用。它还被用于研究其对小鼠中Aβ25-35诱导的受体改变和认知障碍的影响。 PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.

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Chinese name

PHA-543613, 神经元乙酰胆碱受体蛋白 alpha-7 亚基激动剂

English name

PHA-543613

Chinese alias

N- [(3R)-1-氮杂双环 [2.2.2] 辛-3-基] 呋喃 [2,3-c] 吡啶-5-甲酰胺

English alias

(R)-N-(Quinuclidin-3-yl)furo(2,3-C)pyridine-5-carboxamide | Tox21_300448 | DTXSID6047284 | GVVFCAFBYHYGEE-OGFXRTJISA-N | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]uro[2,3-c]pyridine-5-carboxamide | PHA-00543613 | PHA-543,613 | CAS-478149-53-0 | F82142 | HY-10

CAS number

478149-53-0

molecular formula

C15H17N3O2

molecular weight

271.31 g/mol

Exact mass

PSA

58.400 Å²

Logp

1.5

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