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Product introduction

Pifusertib (TAS-117) hydrochloride 是一种有效、选择性别构 Akt 抑制剂 (对 Akt1、2 和 3 的 IC50 分别为 4.8、1.6 和 44 nM)。Pifusertib hydrochloride 激发抗骨髓瘤活性并增强蛋白酶体抑制诱导的致命内质网应激。Pifusertib hydrochloride 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。 Pifusertib (TAS-117) hydrochloride is a potent, selective allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy.

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Chinese name

Pifusertib hydrochloride, 丝氨酸/苏氨酸蛋白激酶 AKT 负异构调节剂

English name

Pifusertib hydrochloride

Chinese alias

匹福塞替布

English alias

G17865 | MS-28465 | HY-19934A | SCHEMBL23122660 | SCHEMBL23122658 | TAS-117 hydrochloride

CAS number

2930090-28-9

molecular formula

C26H25ClN4O2

molecular weight

460.96 g/mol

Exact mass

PSA

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