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名称

p32 Inhibitor M36

分子类型

小分子

别名

p32 抑制剂 M36

英文名称

p32 Inhibitor M36

货号

P646720-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1 In Vitro p32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC 50 of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC 50 of 7.3 μM. p32 Inhibitor M36 is selective for p32 overexpressing cells. p32 Inhibitor M36 is also a potent inhibitor of patient-derived neurospheres with an IC 50 of 2.8 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:p32

生化机理

p32 抑制剂 M36（M36）是一种 p32 线粒体蛋白抑制剂，可直接与 p32 结合并抑制 p32 与 LyP-1 的结合。

CAS号

802555-85-7

分子式

C23H28N8O2

分子量

448.52 g/mol

PubChem编号

416381

Isomeric SMILES

C1CN=C(N1)C2=CC(=CC=C2)NC(=O)NCCCNC(=O)NC3=CC=CC(=C3)C4=NCCN4

IIUPAC Name

1-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3-[3-[[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]carbamoylamino]propyl]urea

INCHI

1S/C23H28N8O2/c32-22(30-18-6-1-4-16(14-18)20-24-10-11-25-20)28-8-3-9-29-23(33)31-19-7-2-5-17(15-19)21-26-12-13-27-21/h1-2,4-7,14-15H,3,8-13H2,(H,24,25)(H,26,27)(H2,28,30,32)(H2,29,31,33)

InChi Key

HHFOXYBNULCICF-UHFFFAOYSA-N

Smiles

C1CN=C(N1)C2=CC(=CC=C2)NC(=O)NCCCNC(=O)NC3=CC=CC(=C3)C4=NCCN4

PubChem CID

416381

溶解性

DMSO : 5 mg/mL (11.15 mM; ultrasonic and warming and heat to 80°C)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

448.234 Da

单同位素质量Monoisotopic Mass

448.234 Da

拓扑极表面积Topological Polar Surface Area

131.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

680

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

-0.1

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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