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Product details

名称

PSB-12062

分子类型

小分子

英文别名

英文名称

PSB-12062

货号

P646739-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PSB-12062 is a potent and selective P2X4 antagonist with an IC 50 of 1.38 μM for human P2X4. In Vitro PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)

生化机理

PSB-12062 是一种强效的选择性 P2X4 拮抗剂，对人类 P2X4 的 IC 50 为 1.38 μM。

CAS号

55476-47-6

分子式

C19H15NO3S

分子量

337.39 g/mol

PubChem编号

2320735

Isomeric SMILES

CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42

IIUPAC Name

10-(4-methylphenyl)sulfonylphenoxazine

INCHI

1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3

InChi Key

DHZNMEIBMACSFH-UHFFFAOYSA-N

Smiles

CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42

PubChem CID

2320735

溶解性

DMSO : 25 mg/mL (74.10 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

337.077 Da

单同位素质量Monoisotopic Mass

337.077 Da

拓扑极表面积Topological Polar Surface Area

55.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

513.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.200

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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