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名称

Pyr6

分子类型

小分子

英文别名

英文名称

Pyr6

货号

P646980-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).IC50 value: 0.49 uM Target: TRPC3 inhibitorPyr6 is a selective SOCE inhibitor (Yonetoku et al., 2008; Sweeney et al., 2009), Pyr6 displayed 37-fold (1.58 OM) higher potency for RBL SOCE than for TRPC3 ROCE, with an IC50 comparable to that of Pyr2 and Pyr3. Pyr6 at 3 uM diminished TRPC3 currents to only 52%. Consistent with inhibition of Orai channel activity Pyr2, Pyr3 or Pyr6 substantially inhibited typical Orai downstream signalling events in RBL mast cells (NFAT activation and degranulation) activated by passive store depletion. Form:Solid

生化机理

Pyr6 是一种 TRPC3 选择性抑制剂，其 IC50 值为 0.49 uM（抑制硫糖金耗竭的原生 RBL-2H3 细胞中的 Ca2+ 流入）：Pyr6 是一种选择性 SOCE 抑制剂（Yonetoku 等人，2008 年；Sweeney 等人，2009 年）。

CAS号

245747-08-4

分子式

C17H9F7N4O

分子量

418.27 g/mol

PubChem编号

10598093

Isomeric SMILES

C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

IIUPAC Name

N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoropyridine-4-carboxamide

INCHI

1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)

InChi Key

XZIQSOZOLJJMFN-UHFFFAOYSA-N

Smiles

C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

PubChem CID

10598093

溶解性

DMSO : ≥ 100 mg/mL (239.08 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

418.066 Da

单同位素质量Monoisotopic Mass

418.066 Da

拓扑极表面积Topological Polar Surface Area

59.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

577.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.600

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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