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Product introduction

PF-07220060 (CDK4/6-IN-6; example A94) is a potent CDK4/CDK6 inhibitor with a K i of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively In Vitro PF-07220060 (CDK4/6-IN-6; example A94) has IC 50 s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Cdk4/cyclin D1 0.6 nM (Ki) cdk6/cyclin D3 13.9 nM (Ki)

Specs ⸢ View details ⸥

Chinese name

PF-07220060

English name

PF-07220060

Chinese alias

English alias

CAS number

2380321-51-5

molecular formula

C22H27ClFN5O3

molecular weight

463.93 g/mol

Exact mass

≥99%

PSA

Logp

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