PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC 50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization In Vitro PARP11 inhibitor ITK7 (ITK7) can potently inhibit PARP11 with an IC 50 value of 14 nM. ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation with an EC 50 value of 13 nM. ITK7 (0, 0.03, 0.1, 0.3, 1, 3 μM; 3 h) inhibits PARP11 auto-MARylation activity in cells and causes PARP11 to dissociate from the nuclear\nenvelope. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HeLa cells Concentration: 0, 0.03, 0.1, 0.3, 1, 3 μM Incubation Time: 3 h Result: Inhibited GFP-PARP11 auto-MARylation activity in a dose-dependent manner in HeLa cells. Form:Solid IC50& Target:IC50: 14 nM (PARP11),13 nM (PARP11-dependent auto-MARylation)