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Product introduction

PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC 50 of 3.64 μM for human PARP10 . PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC 50 s of 27 μM and 11 μM for human PARP2 and human PARP15 , respectively In Vitro PARP10-IN-2 (compound 10) has an IC 50 of 1-2 μM by olony‐formation assay (CFA) in HeLa‐PARP10 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:human PARP10 3.64 μM (IC 50 ) human PARP15 11 μM (IC 50 ) human PARP2 27 μM (IC 50 ) human PARP12 >10 μM (IC 50 ) human PARP16 >10 μM (IC 50 ) human PARP1 >100 μM (IC 50 ) human PARP3 >100 μM (IC 50 ) human PARP4 >100 μM (IC 50 ) human TNKS1 >100 μM (IC 50 ) human TNKS2 >100 μM (IC 50 ) human PARP14 >100 μM (IC 50 )

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Chinese name

PARP10-IN-2

English name

PARP10-IN-2

Chinese alias

PARP10-合一

English alias

CAS number

1042780-52-8

molecular formula

C14H10N2O2

molecular weight

238.24 g/mol

Exact mass

≥98%

PSA

Logp

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