Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

PF-6683324

分子类型

小分子

英文名称

PF-6683324

货号

P648737-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC 50 s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA , TrkB and TrkC , respectively Anti-hyperalgesic effect In Vitro PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC 50 >5 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TrkA 1.9 nM (IC 50 , in cell-based assays) TrkB 2.6 nM (IC 50 , in cell-based assays) TrkC 1.1 nM (IC 50 , in cell-based assays)

生化机理

在基于细胞的试验中，PF-6683324（Trk-IN-4）是一种强效的泛 Trk 抑制剂，对 TrkA、TrkB 和 TrkC 的 IC 50 s 分别为 1.9 nM、2.6 nM 和 1.1 nM。抗镇痛作用。

CAS号

1799788-94-5

分子式

C24H23F4N5O4

分子量

521.46 g/mol

PubChem编号

118189484

Isomeric SMILES

CN1C=C(N=C1)C2=CC(=C(N=C2)O[C@@H]3CCN(C[C@@H]3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N

IIUPAC Name

2-[(3S,4R)-3-fluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]piperidin-4-yl]oxy-5-(1-methylimidazol-4-yl)pyridine-3-carboxamide

INCHI

1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m0/s1

InChi Key

XJIIVPVOGYFVME-AZUAARDMSA-N

Smiles

CN1C=C(N=C1)C2=CC(=C(N=C2)OC3CCN(CC3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N

PubChem CID

118189484

溶解性

DMSO : ≥ 100 mg/mL (191.77 mM)

RIDADR

NONHforallmodesoftransport

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！