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Product details

名称

Pridopidine, 多巴胺 D2 受体调节剂

分子类型

小分子

别名

4-[3-(甲磺酰基)苯基]-1-丙基哌啶 | 普利多比定

英文别名

英文名称

Pridopidine

货号

P648764-5mg

包装规格

5mg

浓度

≥97%

储存温度

-20°C储存

运输条件

超低温冰袋运输

敏感性

对湿度敏感

产品介绍

Pridopidine 是一种多巴胺 (DA) 稳定剂，可用作一种低亲和力的多巴胺 D2 受体 (D2R) 拮抗剂。Pridopidine 高亲和力作用于 sigma 1受体 (S1R)，Ki 值为 70 到 80 nM，比其对 D2R 的亲和力高约 100 倍。 Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.

生化机理

普利多哌啶是一种多巴胺（DA）稳定剂，是一种低亲和力的多巴胺 D2 受体（D2R）拮抗剂。普利多哌啶对 sigma 1 受体（S1R）具有高亲和力，K i 在 70 至 80 nM 之间，比其对 D2R 的亲和力高出约 100 倍。

CAS号

346688-38-8

分子式

C15H23NO2S

分子量

281.41 g/mol

PubChem编号

9795739

Isomeric SMILES

CCCN1CCC(CC1)C2=CC(=CC=C2)S(=O)(=O)C

IIUPAC Name

4-(3-methylsulfonylphenyl)-1-propylpiperidine

INCHI

1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3

InChi Key

YGKUEOZJFIXDGI-UHFFFAOYSA-N

Smiles

CCCN1CCC(CC1)C2=CC(=CC=C2)S(=O)(=O)C

PubChem CID

9795739

溶解性

DMSO : 100 mg/mL (355.35 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

281.145 Da

单同位素质量Monoisotopic Mass

281.145 Da

拓扑极表面积Topological Polar Surface Area

45.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

366.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.600

ALogP

2.6

作用类型

调节剂

作用机制

多巴胺 D2 受体调节剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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