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Product details

名称

PF-06952229

分子类型

小分子

英文别名

英文名称

PF-06952229

货号

P649080-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer In Vivo PF-06952229 (oral gavage; 30 mg/kg; twice daily; 21 days) combines with Palbociclib 21 days results in an improved inhibition of pSMAD2 in the MCF7 ER + xenograft breast cancer tumor model. This combination also leads to a significant increase in survival relative to PF-06952229 monotherapy . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MCF-7 ER + HER2-xenograft breast cancer tumor model Dosage: 30 mg/kg Administration: Oral gavage; twice daily; 44 days Result: Resulted in an increase in tumor growth inhibition when combined with Palbociclib. Form:Solid IC50& Target:IC50: transforming growth factor-beta receptor 1 (TGFbR1)

生化机理

PF-06952229 是一种强效、选择性和口服活性 TGFbR1 抑制剂。PF-06952229 能特异性地与 TGFbR1 结合，阻止 TGFbR1 介导的信号转导。

CAS号

1801333-55-0

分子式

C23H24ClFN4O3

分子量

458.91 g/mol

PubChem编号

118211239

Isomeric SMILES

CC(C)C1=CN=C(C=C1NC2=C(C=NC=C2)C(=O)NC(CO)CO)C3=C(C=CC(=C3)Cl)F

IIUPAC Name

4-[[2-(5-chloro-2-fluorophenyl)-5-propan-2-ylpyridin-4-yl]amino]-N-(1,3-dihydroxypropan-2-yl)pyridine-3-carboxamide

INCHI

1S/C23H24ClFN4O3/c1-13(2)17-10-27-21(16-7-14(24)3-4-19(16)25)8-22(17)29-20-5-6-26-9-18(20)23(32)28-15(11-30)12-31/h3-10,13,15,30-31H,11-12H2,1-2H3,(H,28,32)(H,26,27,29)

InChi Key

IPBLCOKXDQHSQW-UHFFFAOYSA-N

Smiles

CC(C)C1=CN=C(C=C1NC2=C(C=NC=C2)C(=O)NC(CO)CO)C3=C(C=CC(=C3)Cl)F

PubChem CID

118211239

关联CAS

1801333-55-0

溶解性

DMSO : 50 mg/mL (108.95 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

458.152 Da

单同位素质量Monoisotopic Mass

458.152 Da

拓扑极表面积Topological Polar Surface Area

107.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

598.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.400

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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