PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC , acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC 50 of 0.25 μM for Sirt2 , with no effect on Sirt1/Sirt3 (IC 50 s>100 μM) In Vitro PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HeLa cells Concentration: 10 µM Incubation Time: 1-6 hours Result: Caused Sirt2 degradation, but showed no effect on Sirt1 levels. Form:Solid IC50& Target:SIRT2 0.25 μM (IC 50 )