Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

Piromelatine, 褪黑素受体激动剂

分子类型

小分子

别名

吡罗美汀

英文别名

英文名称

Piromelatine

货号

P649870-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,-20°C储存

运输条件

超低温冰袋运输

敏感性

对光线敏感

产品介绍

Piromelatine (Neu-P11) 是褪黑素受体 MT1/MT2 的激动剂，是 5-HT1A 和 5-HT1D 的激动剂，也是 5-HT2B 的拮抗剂。Piromelatine (Neu-P11) 有用于促进睡眠、缓解疼痛、抗神经退行性和抗抑郁等研究的潜能。Piromelatine (Neu-P11) 还具有抑制疼痛相关靶点 P2X3、TRPV1和 Nav1.7 通道的活性。 Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities

CAS号

946846-83-9

分子式

C17H16N2O4

分子量

312.32 g/mol

PubChem编号

24815904

Isomeric SMILES

COC1=CC2=C(C=C1)NC=C2CCNC(=O)C3=CC(=O)C=CO3

IIUPAC Name

N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-oxopyran-2-carboxamide

INCHI

1S/C17H16N2O4/c1-22-13-2-3-15-14(9-13)11(10-19-15)4-6-18-17(21)16-8-12(20)5-7-23-16/h2-3,5,7-10,19H,4,6H2,1H3,(H,18,21)

InChi Key

PNTNBIHOAPJYDB-UHFFFAOYSA-N

Smiles

COC1=CC2=C(C=C1)NC=C2CCNC(=O)C3=CC(=O)C=CO3

PubChem CID

24815904

关联CAS

946846-83-9

MeSH Entry Terms

N-(2-(5-methoxy-indol-3-yl)-ethyl)-4-oxo-4H-pyran-2-carboxamide;Neu-P11;piromelatine

溶解性

DMSO : 250 mg/mL (800.46 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

312.111 Da

单同位素质量Monoisotopic Mass

312.111 Da

拓扑极表面积Topological Polar Surface Area

80.400 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

529.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

1.700

ALogP

1.7

作用类型

激动剂

作用机制

褪黑素受体激动剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！