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Product details

名称

PTGR2-IN-1

英文名称

PTGR2-IN-1

货号

P650236-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PTGR2-IN-1 is a potent PTGR2 inhibitor with an IC 50 of ~0.7 μM. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells. In Vitro A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil

生化机理

PTGR2-IN-1 是一种强效的 PTGR2 抑制剂，其 IC 50 约为 0.7 μM。PTGR2-IN-1 能增加 PTGR2 转染的 HEK293T 细胞中 15-keto-PGE2 依赖性 PPARγ 的转录活性。

CAS号

349093-44-3

分子式

C19H22N2O2

分子量

310.4 g/mol

PubChem编号

912698

Isomeric SMILES

COC1=CC=CC=C1N2CCN(CC2)C(=O)CC3=CC=CC=C3

IIUPAC Name

1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone

INCHI

1S/C19H22N2O2/c1-23-18-10-6-5-9-17(18)20-11-13-21(14-12-20)19(22)15-16-7-3-2-4-8-16/h2-10H,11-15H2,1H3

InChi Key

TVIOYMPBWXQRRQ-UHFFFAOYSA-N

Smiles

COC1=CC=CC=C1N2CCN(CC2)C(=O)CC3=CC=CC=C3

PubChem CID

912698

溶解性

DMSO : 100 mg/mL (322.18 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

310.168 Da

单同位素质量Monoisotopic Mass

310.168 Da

拓扑极表面积Topological Polar Surface Area

32.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

374.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.900

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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