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Product details

名称

PROTAC BET Degrader-1

别名

PROTAC BET 降解剂-1

英文名称

PROTAC BET Degrader-1

货号

P650501-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PROTAC BET Degrader-1 is a PROTAC connected by ligands for Cereblon and BET , decreasing BRD2 , BRD3 , and BRD4 protein levels at low concentration. In Vitro PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC 50 of 4.3 nM, and 45.5 nM for MOLM-13 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:BET

生化机理

PROTAC BET 降解剂-1 是一种由脑龙和 BET 配体连接的 PROTAC，可在低浓度下降低 BRD2、BRD3 和 BRD4 蛋白水平。

CAS号

2093386-22-0

分子式

C44H45N11O9

分子量

871.90 g/mol

Smiles

CCN1C(NC2=C3C4=CC(OC)=C(C(C(C)=NO5)=C5C)C=C4NC3=NC(C(NCCCCNC(COC6=C(C(N7C(CCC8=O)C(N8)=O)=O)C(C7=O)=CC=C6)=O)=O)=N2)=CC(C9CC9)=N1

溶解性

DMSO : ≥ 50 mg/mL (57.35 mM)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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