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Product details

名称

PF-06471553

分子类型

小分子

英文名称

PF-06471553

货号

P650655-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM. In Vitro PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC 50 , >50 μM), DGAT2 (IC 50 , >100 μM), MGAT1 (IC 50 , 14.9 μM), and MGAT2 (IC 50 , 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC 50 of 205 nM (pIC 50 , 6.69). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 92 nM (MGAT3)

生化机理

PF-06471553 是一种强效、选择性口服单酰基甘油酰基转移酶 3 (MGAT3) 抑制剂，IC 50 为 92 nM。

CAS号

1808094-07-6

分子式

C23H25N5O4S

分子量

467.54 g/mol

PubChem编号

122189255

Isomeric SMILES

COC1=CC=CC(=C1)CC(=O)N2CC3=C(C2)C=C(C=C3)S(=O)(=O)NC4=NN(N=C4)C5CCC5

IIUPAC Name

N-(2-cyclobutyltriazol-4-yl)-2-[2-(3-methoxyphenyl)acetyl]-1,3-dihydroisoindole-5-sulfonamide

INCHI

1S/C23H25N5O4S/c1-32-20-7-2-4-16(10-20)11-23(29)27-14-17-8-9-21(12-18(17)15-27)33(30,31)26-22-13-24-28(25-22)19-5-3-6-19/h2,4,7-10,12-13,19H,3,5-6,11,14-15H2,1H3,(H,25,26)

InChi Key

GRXCLNMCJWKTAT-UHFFFAOYSA-N

Smiles

COC1=CC=CC(=C1)CC(=O)N2CC3=C(C2)C=C(C=C3)S(=O)(=O)NC4=NN(N=C4)C5CCC5

PubChem CID

122189255

MeSH Entry Terms

N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2-(2-(3-methoxyphenyl)acetyl)isoindoline-5-sulfonamide;PF-06471553

溶解性

DMSO : ≥ 150 mg/mL (320.83 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

467.163 Da

单同位素质量Monoisotopic Mass

467.163 Da

拓扑极表面积Topological Polar Surface Area

115.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

801.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.300

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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