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Product details

名称

(+)-Penbutolol

别名

(+)-喷布洛尔

英文别名

英文名称

(+)-Penbutolol

货号

P651513-5mg

包装规格

5mg

浓度

≥95%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC 50 of 0.74 μM (+)-Penbutolol is an optical isomer of l-penbutolol with Na + channel-blocking action . In Vitro (+)-penbutolol on the [Ca 2+ ] i -increase induced by LPC is concentration-dependent. (+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10 -6 M, 5×10 -6 M and 10 -5 M, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.74 μM (β-adrenoceptor)

生化机理

(+)-Penbutolol 是一种 β 肾上腺素受体拮抗剂，IC50 为 0.74 μM。(+)-Penbutolol 是 l-penbutolol 的光学异构体，具有阻断 Na + 通道的作用。

CAS号

38363-41-6

分子式

C18H29NO2

分子量

291.43 g/mol

PubChem编号

162302

Isomeric SMILES

CC(C)(C)NC[C@H](COC1=CC=CC=C1C2CCCC2)O

IIUPAC Name

(2R)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol

INCHI

1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m1/s1

InChi Key

KQXKVJAGOJTNJS-OAHLLOKOSA-N

Smiles

CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O

PubChem CID

162302

关联CAS

38363-41-6

溶解性

DMSO : 100 mg/mL (343.14 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

291.22 Da

单同位素质量Monoisotopic Mass

291.22 Da

拓扑极表面积Topological Polar Surface Area

41.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

294

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.2

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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