Praeruptorin B

小分子

白花蛇舌草素B

AKOS037515272 | CCG-268959 | Q-100803 | (-)-Praeruptorin B | CCG-268960 | E80827 | HY-N0082 | (9S,10S)-8,8-Dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromene-9,10-diyl (2Z,2'Z)-bis(2-methylbut-2-enoate) | Praeruptorin D | Praeruptorin B | s9392

Praeruptorin B

P651602-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs) . In Vitro Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:SREBP

Praeruptorin B 是固醇调节元件结合蛋白（SREBPs）的抑制剂。

73069-28-0

C24H26O7

426.46 g/mol

25717254

C/C=C(/C)\C(=O)O[C@@H]1[C@@H](C(OC2=C1C3=C(C=C2)C=CC(=O)O3)(C)C)OC(=O)/C(=C\C)/C

[(9S,10S)-8,8-dimethyl-9-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl] (Z)-2-methylbut-2-enoate

1S/C24H26O7/c1-7-13(3)22(26)29-20-18-16(11-9-15-10-12-17(25)28-19(15)18)31-24(5,6)21(20)30-23(27)14(4)8-2/h7-12,20-21H,1-6H3/b13-7-,14-8-/t20-,21-/m0/s1

PNTWXEIQXBRCPS-UWOGZXHISA-N

CC=C(C)C(=O)OC1C(C(OC2=C1C3=C(C=C2)C=CC(=O)O3)(C)C)OC(=O)C(=CC)C

25717254

73069-28-0,73069-26-8

anomalin;anomalin, (9alpha(E),10alpha(E));anomalin, (9S-(9alpha(Z),10alpha(Z)))-isomer;anomalin, (Z,Z)-isomer;praeruptorin B

DMSO : 25 mg/mL (58.62 mM; ultrasonic and warming and heat to 60°C)

0

7

6

426.168 Da

426.168 Da

88.100 Ų

31

0

835.000

0

1

4.300