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Product details

名称

PROTAC BET Degrader-10

别名

PROTAC BET 降解剂-10

英文名称

PROTAC BET Degrader-10

货号

P651713-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

PROTAC BET Degrader-10 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, connected by ligands for Cereblon and BRD4 , with a DC 50 of 49 nM. Form:Solid

生化机理

PROTAC BET 降解剂-10 是一种强效的 BET 蛋白 BRD4 降解剂，提取自专利 WO2017007612A1（实施例 37），由 Cereblon 和 BRD4 的配体连接而成，DC 50 为 49 nM。

CAS号

1957234-97-7

分子式

C39H39ClN8O6S

分子量

783.29 g/mol

PubChem编号

156588672

INCHI

1S/C39H38ClN8O6S/c1-20-21(2)55-39-32(20)34(23-11-13-25(40)14-12-23)43-27(35-46-45-22(3)47(35)39)18-31(51)41-17-6-4-5-10-29(49)42-19-24-8-7-9-26-33(24)38(54)48(37(26)53)28-15-16-30(50)44-36(28)52/h7-9,11-14,28H,4-6,10,15-19H2,1-3H3,(H,41,51)(H,42,49)(H,44,50,52)

InChi Key

FWSOWKODOMZQCQ-UHFFFAOYSA-N

Smiles

CC1=C(SC2=C1C(=N[C](C3=NN=C(N23)C)CC(=O)NCCCCCC(=O)NCC4=C5C(=CC=C4)C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)C

PubChem CID

156588672

溶解性

DMSO : 100 mg/mL (127.67 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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