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Product details

名称

PSB-12062

分子类型

小分子

英文名称

PSB-12062

货号

P654727-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

PSB-12062 is a potent and selective P2X4 antagonist with an IC 50 of 1.38 μM for human P2X4. In Vitro PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)

生化机理

PSB-12062 是一种强效的选择性 P2X4 拮抗剂，对人类 P2X4 的 IC 50 为 1.38 μM。

CAS号

55476-47-6(DMSO)

分子式

C19H15NO3S

分子量

337.39 g/mol

Smiles

CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3OC4=CC=CC=C42

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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