PS372424 hydrochloride

PS372424 盐酸盐

PS372424 hydrochloride

P654882-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation In Vitro PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation. PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells not in CXCR3 - T cells. PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC 50 of 42±21 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CXCR3 + T cells and CXCR3 - T cells Concentration: 10, 50, 100, or 200 nM Incubation Time: 30 minutes Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells. Did not result in phosphorylation of CCR5 on CXCR3 - T cells. IC50& Target:Human CXCR3

盐酸 PS372424 是 CXCL10 的三个氨基酸片段，是一种具有抗炎活性的特异性人类 CXCR3 激动剂。盐酸 PS372424 可在人源化关节炎模型中阻止人 T 细胞迁移。

1596362-29-6(DMSO)

C33H45ClN6O4

625.20 g/mol

C1CCC(CC1)CNC(=O)C(CCCN=C(N)N)NC(=O)C2CC3=CC=CC=C3CN2C(=O)CCC(=O)C4=CC=CC=C4.Cl