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Product details

名称

8-异戊烯基柚皮素

分子类型

小分子

英文名称

8-Prenylnaringenin

货号

P697820-5mg

包装规格

5mg

级别

Moligand™

浓度

≥98%

储存温度

2-8°C储存,避光

运输条件

冰袋运输

敏感性

对光线敏感

产品介绍

8-prenylnaringenin 是一种从啤酒花穗 Humulus lupulus 中分离到的异戊烯类黄酮，具有细胞毒性。8-prenylnaringenin 能通过诱导内源性、外源性通路介导的凋亡，对 HCT-116 结肠癌细胞产生抗增殖活性。8-Prenylnaringenin 能通过激活小鼠 Akt 磷酸化途径，促进其从静止诱导的停用性肌肉萎缩中恢复。 8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice

CAS号

53846-50-7

分子式

C20H20O5

分子量

340.37 g/mol

PubChem编号

480764

Isomeric SMILES

CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC=C(C=C3)O)C

IIUPAC Name

(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one

INCHI

1S/C20H20O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9,18,21-23H,8,10H2,1-2H3/t18-/m0/s1

InChi Key

LPEPZZAVFJPLNZ-SFHVURJKSA-N

Smiles

CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)O)C

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

340.131 Da

单同位素质量Monoisotopic Mass

340.131 Da

拓扑极表面积Topological Polar Surface Area

87.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

504.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.300

Reaxy-Rn

1690350

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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