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名称

脯氨酸特异性内切蛋白酶来源于黄杆菌属

货号

P755309-50U

包装规格

50U

浓度

lyophilized powder,≥5.0 units/mg solid

产品介绍

脯氨酸特异性内肽酶可用于确定含有脯氨酸残基的肽和蛋白质的氨基酸序列。脯氨酸特异性内肽酶可用于癌症、神经病学和糖尿病研究。脯氨酰内肽酶 (PEP)可用作神经精神疾病（如应激障碍、抑郁症和精神分裂症）的药物靶标。 Proline specific endopeptidase is useful for the determination of amino acid sequences of peptides and proteins containing proline residues. Proline specific endopeptidases may be useful in cancer, neurology and diabetes research . Prolyl endopeptidase (PEP) may be used as a drug target for neuropsychiatric diseases such as stress disorder, depression, and schizophrenia .

生化机理

内肽酶是一种蛋白水解肽酶，会破坏非末端氨基酸的肽键。产物 E1411专用于脯氨酸 (Pro)。脯氨酰内肽酶 (PEP) 的作用机制被认为是诱导契合机制，其中未变性酶以构象柔性开放状态存在，但在结合底物后变为封闭状态。

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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