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Product introduction
Information APX-115 free base (Ewha-18278 free base) is a potent, orally active inhibitor ofpan NADPH oxidase (pan-Nox)with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules includingMCP-1/CCL2,IL-6, andTNFαin the diabetic kidney. Targets MCP-1/CCL2 ; IL-6 ; TNFα ; NOX2 (Cell-free assay); NOX4 (Cell-free assay) 33094,; 0.57 μM(Ki); 0.63 μM(Ki)
Chinese name
APX-115自由基
English name
APX-115 free base
Chinese alias
-
English alias
1-(pyridin-2-yl)-3-phenyl-4-propyl-1H-pyrazol-5-ol | 1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)- | APX115;APX 115;Ewha-18278;Ewha18278 | S0777 | Isuzinaxib | EWHA-18278 (free base) | APX-115 free base | 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazo
CAS number
1270084-92-8
molecular formula
C17H17N3O
molecular weight
279.34 g/mol
Exact mass
-
PSA
45.200 Ų
Logp
2.994
Technical Documents
「No technical documents」
Related
「No upstream and downstream information yet」
Articles
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Research chemical CAS 1270084-92-8 10mM 1ml

Research chemical CAS 1270084-92-8 10mM 1ml, complete specifications, for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:P793474-1ml
Product model:1ml
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Lead Time:30days
sold 316 Items
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