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Product introduction

Pexidartinib (PLX-3397) 是一种有效的，具有口服活性的、选择性ATP-竞争性的集落刺激因子 1 (CSF1R 或 M-CSFR) 和 c-Kit 抑制剂，IC50 值分别为 20 和 10 nM。Pexidartinib (PLX-3397) 对 c-Kit 和 CSF1R 的选择性是对其他相关激酶的 10-100 倍，例如 FLT3，KDR (VEGFR2)，LCK，FLT1 (VEGFR1) 和 NTRK3 (TRKC)，IC50 值分别为 160，350，860，880 和 890 nM。Pexidartinib (PLX-3397) 可以诱导细胞凋亡 (apoptosis)，具有抗肿瘤活性。

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Chinese name

Pexidartinib,MCSF受体抑制剂, 干细胞生长因子受体抑制剂

English name

Pexidartinib

Chinese alias

培西达替尼

English alias

CML-261 | D11270 | PEXIDARTINIB [MI] | N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine;Pexidartinib | CCG-268862 | MFCD28900745 | EX-A589 | SY047897 | 3-Pyridinemethanamine, N-(5-((5-chloro-1H-p

CAS number

1029044-16-3

molecular formula

C20H15ClF3N5

molecular weight

417.81 g/mol

Exact mass

PSA

66.500 Å²

Logp

4.5

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Pexidartinib (PLX3397) 10mM in DMSO 1ml

Name: Pexidartinib (PLX3397) 10mM in DMSO 1ml
Brand: 麦克林
SKU: P796070-1ml

Pexidartinib (PLX3397) 10mM in DMSO 1ml Macklin 1029044-16-3, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：P796070-1ml

Product model：1ml

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Lead Time：30days

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Pexidartinib (PLX3397) 10mM in DMSO 1ml

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