Mepyramine maleate 是第一代抗组胺剂，为 histamine H1 受体拮抗剂，对 H1，H2 和 H3 受体的 Kd 值分别为 0.8 nM，5200 nM 和 >3000 nM，对 H1 受体的 pKd 值为 9.4。 最大吸收波长310(EtOH) nm Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor. application： Pyrilamine maleate salt has been used: to treat Cassiopea sp. as H1 receptor antagonist to intraperitoneally inject mice to prevent the release of endogenous histamine in membrane binding assay to determine the Ki values and in the comparative inhibitory concentration (IC50) studies by whole-cell patch clamp technique