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应用 Suzuki-Miyaura 交叉耦合；钌催化不对称氢化；用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括：VEGF，极光，Rho（岩石），Janus 激酶 2 (JAK)，c-MET，ALK，S-亚硝基谷胱甘肽还原酶，CDC7，乙酰辅酶A羧化酶促存活 Bcl-2 蛋白，病毒 RNA 依赖性 RNA 聚合酶，长链脂肪酸延长酶 6，PI3，AKT，Chk1，蛋白激酶 B； 1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

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Chinese name

4-吡唑硼酸频哪醇酯

English name

4-Pyrazoleboronic acid pinacol ester

Chinese alias

1H-吡唑-4-硼酸频哪醇酯 | 4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑 | 吡唑-4-硼酸凤梨醇酯 | 2-二氧硼烷-2-基)-1H-吡唑 | 4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷

English alias

CAS number

269410-08-4

molecular formula

(CH3)4C2O2BC3N2H3

molecular weight

194.04 g/mol

Exact mass

≥98%

PSA

47.100 Å²

Logp

Technical Documents

269410-08-4 | 4-Pyrazoleboronic acid pinacol ester.pdf
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