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Product introduction
Brepocitinib (PF-06700841) 是一种有效的 JAK1 和 TYK2 双重抑制剂, IC50 值分别为 17 nM 和 23 nM。Brepocitinib 还分别以 IC50 值为 77 nM 和 6.49 μM 抑制 JAK2 和 JAK3。 应用 PF-06700841作为Janus激酶1抑制剂,研究其对佐剂诱导型关节炎(AIA)大鼠模型的治疗作用。它也用作小鼠中干扰素-α/β受体α链(IFNAR1)信号转导接头蛋白酪氨酸激酶(2TYK2)的抑制剂。
Chinese name
PF-06700841, 酪氨酸蛋白激酶 JAK1 抑制剂
English name
PF-06700841
Chinese alias
-
English alias
GTPL10459 | UNII-3X8387Q25N | Brepocitinib (USAN) | [(1S)-2,2-difluorocyclopropyl]-[(1R,5S)-3-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | compound 23 [PMID: 30113844] | 1883299-62-4 | WHO 11169 | Brepociti
CAS number
1883299-62-4
molecular formula
C18H21F2N7O
molecular weight
389.4 g/mol
Exact mass
-
PSA
79.200 Ų
Logp
1.608
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PF-06700841 98% 5mg

PF-06700841 98% 5mg CAS 1883299-62-4, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:P881007-5mg
Product model:5mg
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Lead Time:30days
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