2-（吡啶-2-基）异丙基胺（PIP-胺）是一种叔胺。由PIP-胺已开发出可用于C-H键官能化的双齿导向基团。 用途： Shi助剂是一种通过铜介导的C-H 活化而使芳烃羟基化的导向基团。这种辅基可以通过酸介导的水解作用除去，并且已经证明可以进行克级规模的处理。 折射率n/D 1.516 2-(Pyridin-2-yl)isopropyl amine (PIP-amine) is a tertiary amine. A bidentate directing group, useful for the functionalization of C-H bond, has been developed from PIP-amine. Purpose： The Shi Auxiliary is a powerful directing group for the hydroxylation of arenes through copper-mediated C-H activation. This useful auxiliary can be removed through acid-mediated hydrolysis and has shown to be done on gram-scale.