Prodipine, a diphenyl-phosphonate derivative. The IC 50 s of Prodipine for purified and plasma Dipeptidyl peptidase IV ( DPP IV ) from the rabbit are 4.5 μM and 30 μM, respectively. In Vitro Prodipine, a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC 50 values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remaines unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV)