PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A) . PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs) In Vitro PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level. A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: B153 and HUES9 human pluripotent stem cells (hPSCs) Concentration: 20 µM Incubation Time: 12 hours Result: Reduced TOP2A expression at the protein level. Form:Solid IC50& Target:topoisomerase II alpha